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Ramipril is effective in preventing sudden death and arrhythmia

Keyword:heart Failure Ramipril Arrhyth

In high-risk patients of clinical heart failure, significant left ventricular systolic dysfunction or vascular disease, ACE inhibitors can reduce cardiovascular death, myocardial infarction, stroke, heart failure hospitalization and need for revascularization risk. In these patients, ACE inhibitors can also reduce sudden death or arrhythmia-related cardiac death. In the McMaster University in Hamilton of Canada Dr. Teo KK and his colleagues select 9297 cases of patients of no clinically significant heart failure or left ventricular dysfunction in test of Heart Outcomes Prevention Evaluation (HOPE). They evaluated the ramipril's effect on the heart sudden death or resuscitated cardiac arrest.

In the average duration of 4.5 years of follow-up period, compared with patients who were randomized to receive placebo-treated, the accidental death, defined arrhythmic death or resuscitated cardiac arrest patient who use ramipril, and the incidence decreased 21%. Randomly assigned to take ramipril patients, 155 patients (3.3%) took place the mixed prognosis of events, while the placebo group is 195 patients (4.2%) (RR 0.79, 95% CI 0.64-0.98, P = 0.028). Ramipril is effective in preventing sudden death and arrhythmiaIn addition, the ramipril group lethal death (accidental or defined arrhythmic death: RR 0.81, 95% CI 0.64-1.02, P = 0.072) and the events of non-fatal primary prognosis (the recovered cardiac arrest: RR 0.65 , 95% CI 0.38-1.13, P = 0.127) occurred in downward trend.

Dr Teo concluded that in high-risk patients of no clinical heart failure or without obvious left ventricular systolic dysfunction, ramipril can reduce fatal and non-fatal incidents of serious arrhythmia.

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Data:2009-09-16 18:55Click:
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